Novel CCR1 antagonists with improved metabolic stability

Bioorg Med Chem Lett. 2004 May 3;14(9):2175-9. doi: 10.1016/j.bmcl.2004.02.022.

Abstract

The synthesis, biological activity, and pharmacokinetic profile of novel CCR1 antagonists are described.

MeSH terms

  • Animals
  • Dogs
  • Haplorhini
  • Pharmacokinetics
  • Receptors, CCR1
  • Receptors, Chemokine / antagonists & inhibitors*

Substances

  • Receptors, CCR1
  • Receptors, Chemokine